Energy storage synovial membrane control

How does energy metabolism affect synovial osteogenic transformation?

In contrast, metabolomic analysis revealed that high energy metabolism (TCA cycle) expression provides the energy required for synovial osteogenic transformation. Alterations in energy metabolism, cartilage repair, and osteogenic mechanisms are critical.

What is the role of synovial ECM in tissue homeostasis?

In conclusion, the role of synovial ECM in tissue homeostasis is to mediate appropriate cellular responses and phenotypes and to guide physiologically and pathologically related cellular behavior to maintain the mechanical integrity and function of synovial membranes.

What reflects a high-energy metabolic state in the synovium and synovial fluid?

Elevated TCA cycle activity in the synovium and synovial fluid reflects a high-energy metabolic state. Arginine is a semiessential amino acid that serves as a precursor for various molecules, including urea, nitric oxide, proline, glutamate, creatine, and agmatine.

Why are synovial ECMs important?

Synovial ECMs are highly plastic, providing biochemical and necessary structural support to cells while regulating organ development and maintaining body balance. Arthritis occurs when the balance of the ECM components in the synovium is disrupted.

Do synovial fluid mesenchymal stem cells attract MSCs?

Morphological aspects of synovial fluid mesenchymal stem cells isolated from (A) healthy persons and (B) patients with osteoarthritis. Cell cluster (arrowhead) is observed in synovial fluid mesenchymal stem cells from patients with osteoarthritis. SF seems to have a role in attracting MSCs whether from BM or other sources on the synovial joint.

Are synovium and synovial fluid involved in koa pathology?

GO enrichment analysis revealed that the differentially expressed proteins in both the synovium and synovial fluid were involved in cell adhesion, extracellular matrix organization, and collagen fibril organization, suggesting a shared biological function between these tissues in KOA pathology.